Title of article
Synthesis and antisense properties of oligodeoxyribonucleotides containing C5-substituted arabinofuranosyluracil
Author/Authors
Hiroaki Ozaki، نويسنده , , Kiyohiro Nakajima، نويسنده , , Masayasu Kuwahara، نويسنده , , Hiroaki Sawai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1115
To page
1118
Abstract
An oligodeoxyribonucleotide (ODN) containing three C5-substituted arabinofuranosyluracils was synthesized by the post-synthetic modification method from the ODN containing three C5-substituted 2,2′-anhydrouridines. The stability of the modified ODN/DNA duplex was lower than that of the corresponding normal duplex but that of the modified ODN/RNA duplex showed little change. The modified ODN could induce RNase H activity and was resistant against nuclease.
Keywords
Post-syntheticmodification , Antisense. , C5-substituted arabinofuranosyluracil
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794142
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