Author/Authors :
Brian Dyck، نويسنده , , Val S. Goodfellow، نويسنده , , Teresa Phillips، نويسنده , , Jonathan Grey، نويسنده , , Mustapha Haddach، نويسنده , , Martin Rowbottom، نويسنده , , Gregory S. Naeve، نويسنده , , Brock Brown، نويسنده , , John Saunders، نويسنده ,
Abstract :
Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB1 receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analogous triazoles are less so due to the absence of an additional substituent on the azole ring.
