Author/Authors :
Hitoshi Kurata، نويسنده , , Sayaka Suzuki، نويسنده , , Yasuo Ohhata، نويسنده , , Takuya Ikeda، نويسنده , , Toru Hasegawa، نويسنده , , Ken Kitayama، نويسنده , , Toshimori Inaba، نويسنده , , Keita Kono، نويسنده , , Takafumi Kohama، نويسنده ,
Abstract :
A series of 4-oxo-1-phenyl-1,4-dihydroquinolines possessing a linker and an ammonio moiety were synthesized and found to inhibit the apical sodium-dependent bile acid transporter (ASBT). The potency of ASBT inhibition varied with the position and length of the linking tether. Compound 21e effectively lowered the total serum cholesterol levels in hamsters.
