Author/Authors :
Charles G. Caldwell، نويسنده , , Ping Chen، نويسنده , , Jiafang He، نويسنده , , Emma R. Parmee، نويسنده , , Barbara Leiting، نويسنده , , Frank Marsilio، نويسنده , , Reshma A. Patel، نويسنده , , Joseph K. Wu، نويسنده , , George J. Eiermann، نويسنده , , Aleksandr Petrov، نويسنده , , Huaibing He، نويسنده , , Kathryn A. Lyons، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده ,
Abstract :
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.
