Title of article :
Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine
Author/Authors :
Dong-Rack Choi، نويسنده , , Jung-Han Shin، نويسنده , , Jin Yang، نويسنده , , Sue Hye Yoon، نويسنده , , Yong Ho Jung، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.
Keywords :
Antibacterial activity , flu oroquinolone , fax: +82-3144-69556 , oxiimino pyrrolidine.* Corresponding author. Tel.: +82-3144-52485 , e-mail: org301@iris.dwcrc.co.kr
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
