Title of article :
Design and synthesis of novel small molecule N/OFQ receptor antagonists
Author/Authors :
Zhengming Chen، نويسنده , , R.Richard Goehring، نويسنده , , Kenneth J. Valenzano، نويسنده , , Donald J. Kyle، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Small molecule N/OFQ receptor antagonists were designed and synthesized to further investigate the therapeutic potential of N/OFQ receptor modulators. The resulting octahydrobenzimidazol-2-ones 14 and 23 show excellent antagonistic activity towards both N/OFQ and mu receptors with high affinity to the human N/OFQ receptor.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
