Author/Authors :
Gary C. Look، نويسنده , , Charles Vacin، نويسنده , , Tracy M. Dias، نويسنده , , Sun Ho، نويسنده , , Thuy H. Tran، نويسنده , , Laurance L. Lee، نويسنده , , Cedric Wiesner، نويسنده , , Flora Fang، نويسنده , , Andrea Marra، نويسنده , , Don Westmacott، نويسنده , , Alexander E. Hromockyj، نويسنده , , Martin M. Murphy، نويسنده , , John R. Schullek، نويسنده ,
Abstract :
Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
