Title of article
Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituents
Author/Authors
Jens-Uwe Peters، نويسنده , , Silja Weber، نويسنده , , Stéphane Kritter، نويسنده , , Peter Weiss، نويسنده , , Angelina Wallier، نويسنده , , Markus Boehringer، نويسنده , , Michael Hennig، نويسنده , , Bernd Kuhn، نويسنده , , Bernd-Michael Loeffler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1491
To page
1493
Abstract
The influence of aromatic substitution on a newly discovered class of inhibitors of dipeptidyl peptidase IV was investigated. A 105-fold increase in potency was achieved by the optimization of aromatic substituents in a parallel chemistry program. The observed SAR could be explained by an X-ray structure of the protein–ligand complex.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794219
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