Title of article
Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification
Author/Authors
Vadapalli Chandrasekhar، نويسنده , , Pravas Deria، نويسنده , , Venkatasubbaiah Krishnan، نويسنده , , Arunachalampillai Athimoolam، نويسنده , , Sanjay Singh، نويسنده , , C. Madhavaiah، نويسنده , , S.G. Srivatsan، نويسنده , , Sandeep Verma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1559
To page
1562
Abstract
Pendant pyrazolylcyclophosphazene containing hybrid cross-linked polymer (CPPL) has been utilized for binding Zn(II). The metalated polymer (CPPL–Zn) has been found to be very effective catalyst for the hydrolysis of a RNA model phosphodiester substrate [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP]. In addition, CPPL–Zn also cleaved supercoiled plasmid DNA pBR322 thus providing a novel structural motif of inorganic–organic hybrid polymers as synthetic nucleases.
Keywords
Cyclophosphazene , Catalyst , zinc , Pendant polymer , Phosphate ester , hydrolysis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794234
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