Title of article :
Synthesis and biological activity of selective azasugar-based TACE inhibitors
Author/Authors :
Takahiro Tsukida، نويسنده , , Hideki Moriyama، نويسنده , , Yoshimasa Inoue، نويسنده , , Hirosato Kondo، نويسنده , , Kohichiro Yoshino، نويسنده , , Shin-ichiro Nishimura، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
