Author/Authors :
Keith G. Watson، نويسنده , , Rachel Cameron، نويسنده , , Rob J. Fenton، نويسنده , , David Gower، نويسنده , , Stephanie Hamilton، نويسنده , , Betty Jin، نويسنده , , Guy Y. Krippner، نويسنده , , Angela Luttick، نويسنده , , Darryl McConnell، نويسنده , , Simon J.F. MacDonald، نويسنده , , Andy M. Mason، نويسنده , , Van Nguyen، نويسنده , , Simon P. Tucker، نويسنده , , Wen-Yang Wu، نويسنده ,
Abstract :
A set of trimeric and tetrameric derivatives 6–11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discrete multimeric compounds are all significantly more antiviral than zanamivir and also show outstanding long-lasting protective activity when tested in mouse influenza infectivity experiments.
