Title of article
Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists
Author/Authors
Shelley Allen، نويسنده , , Bradley Newhouse، نويسنده , , Aaron S. Anderson، نويسنده , , Benjamin Fauber، نويسنده , , Andrew Allen، نويسنده , , David Chantry، نويسنده , , Christine Eberhardt، نويسنده , , Joshua Odingo، نويسنده , , Laurence E. Burgess، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
1619
To page
1624
Abstract
Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening. Subsequent lead optimization efforts resulted in defined structure–activity relationships and the identification of potent antagonists (compounds 90 and 91) that inhibited the chemotaxis of Th2 T-cells in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794246
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