Author/Authors :
Shelley Allen، نويسنده , , Bradley Newhouse، نويسنده , , Aaron S. Anderson، نويسنده , , Benjamin Fauber، نويسنده , , Andrew Allen، نويسنده , , David Chantry، نويسنده , , Christine Eberhardt، نويسنده , , Joshua Odingo، نويسنده , , Laurence E. Burgess، نويسنده ,
Abstract :
Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening. Subsequent lead optimization efforts resulted in defined structure–activity relationships and the identification of potent antagonists (compounds 90 and 91) that inhibited the chemotaxis of Th2 T-cells in vitro.
