Title of article
Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists
Author/Authors
Donna M Huryn، نويسنده , , Susan Ashwell، نويسنده , , Reinhardt Baudy، نويسنده , , Darren B. Dressen، نويسنده , , William Gallaway، نويسنده , , Francine S Grant، نويسنده , , Andrei Konradi، نويسنده , , Robert W Ley، نويسنده , , Susan Petusky، نويسنده , , Michael A. Pleiss، نويسنده , , Dimitri Sarantakis، نويسنده , , Christopher M Semko، نويسنده , , Mary M Sherman، نويسنده , , Cesar Tio، نويسنده , , Lu Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1651
To page
1654
Abstract
A pro-drug strategy to identify orally efficacious VLA-4 antagonists is described. Potential pro-drugs were evaluated for their physical chemical characteristics and in vitro properties, including solubility, stability, permeability and plasma stability. Based on this characterization, promising compounds were identified for in vivo pharmacokinetic evaluation. These studies resulted in the identification of a pro-drug that exhibited desirable blood levels in PK studies in several different species.
Keywords
Physico-chemical characterization , prodrugs , VLA-4 antagonist. , cell adhesion
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794253
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