Title of article
Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B
Author/Authors
Stefan B?urle، نويسنده , , Thorsten Blume، نويسنده , , Judith Günther، نويسنده , , Daniela Henschel، نويسنده , , Roman C. Hillig، نويسنده , , Manfred Husemann، نويسنده , , Anne Mengel، نويسنده , , Christian Parchmann، نويسنده , , Elke Schmid، نويسنده , , Werner Skuballa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
1673
To page
1677
Abstract
Based on molecular modeling studies, macrocyclic inhibitors of phosphatase cdc25B were synthetically derived from steroids. A preliminary SAR for this new template was elaborated. A series of compounds shows inhibition of cdc25B in the low micromolar range and good selectivity versus other phosphatases. The compounds did not show a significant antiproliferative effect in MaTu or HaCaT cells.
Keywords
Steroids , Macrocycles , Molecular modeling , Phosphatases , Templates.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794258
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