Title of article
π-Delocalized β-carbolinium cations as potential antimalarials
Author/Authors
Kiyosei Takasu، نويسنده , , Tsubasa Shimogama، نويسنده , , Chalerm Saiin، نويسنده , , Hye Sook Kim، نويسنده , , Yusuke Wataya، نويسنده , , Masataka Ihara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1689
To page
1692
Abstract
Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic structure and antimalarial efficacy.
Keywords
Antimalarials , DLC’s , total synthesis , b-Carbolines , Selective toxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794261
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