Title of article
The inhibition of metallo-β-lactamase by thioxo-cephalosporin derivatives
Author/Authors
Wing Y. Tsang، نويسنده , , Anupma Dhanda، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده , , Jean-Marie Frère and Jozef Van Beeumen، نويسنده , , Moreno Galleni، نويسنده , , Michael I. Page، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1737
To page
1739
Abstract
The 8-thioxocephalosporins are poor substrates for the B. cereus metallo β-lactamase (kcat/Km=61.4 M−1 s−1) and act as weak competitive inhibitors (Ki 700 μM). The hydrolysis product of thioxocephalosporin, a thioacid, also inhibits the enzyme competitively with a Ki=96 μM, whereas the cyclic thioxo-piperazinedione, formed by intramolecular aminolysis of thioxocephalexin has a Ki of 29 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794271
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