Author/Authors :
Chong Hyun Ryu، نويسنده , , Mi Jung Jang، نويسنده , , Jeong Wha Jung، نويسنده , , Juhyun Park، نويسنده , , Hye-Young Choi، نويسنده , , Young-Ger Suh، نويسنده , , Uhtaek Oh، نويسنده , , Hyeung-geun Park، نويسنده , , Jeewoo Lee، نويسنده , , Hyun-Joo Koh، نويسنده , , Joo-Hyun Mo، نويسنده , , Yung Hyup Joo، نويسنده , , Young-Ho Park، نويسنده , , Hee-Doo Kim، نويسنده ,
Abstract :
A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 μM which is 10-fold more potent than capsazepine.
