Author/Authors :
Joo-Hyun Moh، نويسنده , , Young Hoon Choi، نويسنده , , Kyoung Min Lim، نويسنده , , Ki-Wha Lee، نويسنده , , Song Seok Shin، نويسنده , , Jin Kyu Choi، نويسنده , , Hyun-Joo Koh، نويسنده , , Chia-Shin Chung، نويسنده ,
Abstract :
2,2-Dimethyl-4-phenyl-5-{4-(methylsulfinyl)phenyl}-3(2H)furanone derivatives, 3 and 6, were shown to be effectively transformed in vivo into the corresponding methylsulfone derivatives 1 and 4, when orally administered to rats. Pharmacological implications for use of sulfoxide analogues 3 and 6 are discussed as prodrugs to potent selective COX-2 inhibitors 1 and 4.
