Title of article
Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists
Author/Authors
Nagaaki Sato، نويسنده , , Takunobu Shibata، نويسنده , , Makoto Jitsuoka، نويسنده , , Toshiyuki Ohno، نويسنده , , Toshiyuki Takahashi، نويسنده , , Tomoko Hirohashi، نويسنده , , Tetsuya Kanno، نويسنده , , Hisashi Iwaasa، نويسنده , , Akio Kanatani، نويسنده , , Takehiro Fukami، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1761
To page
1764
Abstract
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure–activity relationships and identification of potent 4-alkoxy derivatives are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794276
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