Author/Authors :
Anandan Palani، نويسنده , , Sundeep Dugar، نويسنده , , John W. Clader، نويسنده , , William J. Greenlee، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Jean E. Lachowicz، نويسنده ,
Abstract :
Low molecular weight amide derivatives were synthesized and evaluated as M2 receptor antagonists for the treatment of Alzheimerʹs disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M2 receptor antagonists with structural features different from our clinical candidate 1.
