Title of article
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release
Author/Authors
Peter A. Crooks، نويسنده , , Joshua T. Ayers، نويسنده , , Rui Xu، نويسنده , , Sangeetha P. Sumithran، نويسنده , , Vladimir P. Grinevich، نويسنده , , Lincoln H. Wilkins Jr.، نويسنده , , A. Gabriela Deaciuc، نويسنده , , David D. Allen، نويسنده , , Linda P. Dwoskin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
1869
To page
1874
Abstract
N-n-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogues exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood–brain barrier choline transporter.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794301
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