Author/Authors :
Peter A. Crooks، نويسنده , , Joshua T. Ayers، نويسنده , , Rui Xu، نويسنده , , Sangeetha P. Sumithran، نويسنده , , Vladimir P. Grinevich، نويسنده , , Lincoln H. Wilkins Jr.، نويسنده , , A. Gabriela Deaciuc، نويسنده , , David D. Allen، نويسنده , , Linda P. Dwoskin، نويسنده ,
Abstract :
N-n-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogues exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood–brain barrier choline transporter.
