Title of article
Contemporary paradigms for cholinergic ligand design guided by biological structure
Author/Authors
Palmer Taylor and Jill Trewhella، نويسنده , , Scott B. Hansen، نويسنده , , Todd T. Talley، نويسنده , , Ryan E. Hibbs، نويسنده , , Zoran Radi ، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1875
To page
1877
Abstract
The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794302
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