Title of article
Hydroxytriamides as potent γ-secretase inhibitors
Author/Authors
C. V. C. Prasad، نويسنده , , Jeffrey W. Noonan، نويسنده , , Charles P. Sloan، نويسنده , , Wai Lau، نويسنده , , Shikha Vig، نويسنده , , Michael F. Parker، نويسنده , , David W. Smith، نويسنده , , Steven B. Hansel، نويسنده , , Craig T. Polson، نويسنده , , Donna M. Barten، نويسنده , , Kevin M. Felsenstein، نويسنده , , Susan B. Roberts، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
1917
To page
1921
Abstract
Using a cell-based assay, we have identified optimal residues and key recognition elements necessary for inhibition of γ-secretase. An (S)-hydroxy group or 3,5-difluorophenylacetyl group at the amino terminus and N-methyltertiary amide moiety at the carboxy terminus provided potent γ-secretase inhibitors with an IC50<10 nM.
Keywords
e-mail: prasad.chaturvedula@bms.com , fax: +1-203-677-7702 , Hydroxytriamides , g-Secretase.* Corresponding author. Tel.: +1-203-677-6699
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794310
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