Title of article
Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors
Author/Authors
Giancarlo Cravotto، نويسنده , , Gianni Balliano، نويسنده , , Bruna Robaldo، نويسنده , , Simonetta Oliaro-Bosso، نويسنده , , Stefano Chimichi، نويسنده , , Marco Boccalini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1931
To page
1934
Abstract
A few naturally occurring prenyl- and prenyloxycoumarins and several new related synthetic derivatives were evaluated as inhibitors of squalene-hopene cyclase (SHC), a useful model enzyme, to predict their interactions with oxidosqualene cyclase (OSC). Umbelliprenin-10′,11′-monoepoxide (IC50 2.5 μM) and the corresponding 6′,7′-10′,11′ diepoxide (IC50 1.5 μM) were the most active enzyme inhibitors.
Keywords
Prenylcoumarins , Oxidosqualenecyclase , Squalene hopene cyclase , Umbelliprenin. , Selective epoxydation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794313
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