Title of article :
Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor
Author/Authors :
Afshin Zarghi، نويسنده , , P. N. Praveen Rao، نويسنده , , Edward E. Knaus، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, possessing a N-acetylsulfonamido pharmacophore, has been identified as a potent and selective COX-2 inhibitor that has the potential to acetylate the COX-2 isozyme.
Keywords :
N-Acetylsulfonamido , COX-2 inhibition.* Corresponding author. Tel.: +1-780-492-5993 , e-mail: eknaus@pharmacy.ualberta.ca , fax: +1-780-492-1217
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
