Title of article
Synthesis and biochemical properties of E-ring modified luotonin A derivatives
Author/Authors
Ali Cagir، نويسنده , , Shannon H Jones، نويسنده , , Brian M Eisenhauer، نويسنده , , Rong Gao، نويسنده , , Sidney M. Hecht and Stewart Shuman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2051
To page
2054
Abstract
Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I–DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.
Keywords
Topoisomerase I poisons , antineoplastic agents , Cytotoxicalkaloids.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794336
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