Title of article
Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles
Author/Authors
Ana Carolina Barrios Sosa، نويسنده , , Diane H. Boschelli، نويسنده , , Fei Ye، نويسنده , , Jennifer M. Golas، نويسنده , , Frank Boschelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2155
To page
2158
Abstract
A series of 7-ethynyl and 7-ethenyl-4-anilino-3-quinolinecarbonitriles were synthesized and tested for Src inhibition. Derivatives bearing a C-6 methoxy group and 2,4-dichloro-5-methoxyaniline at C-4 showed optimal inhibition of Src enzymatic and cellular activity. The ethenyl and ethynyl groups were incorporated at C-7 utilizing a Stille, Heck, or Sonogashira coupling reaction.
Keywords
Src inhibitors , Kinase inhibitors , Quinolinecarbonitriles. , tyrosine kinase , Src kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794358
Link To Document