Title of article
Betulinic acid and its derivatives as anti-angiogenic agents
Author/Authors
Rama Mukherjee، نويسنده , , Manu Jaggi، نويسنده , , Praveen Rajendran، نويسنده , , Mohammad J.A Siddiqui، نويسنده , , Sanjay K. Srivastava، نويسنده , , Anand Vardhan Bhalla، نويسنده , , Anand C Burman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2181
To page
2184
Abstract
Betulinic acid (1) significantly caused cytotoxicity to endothelial cell line ECV304 (IC50 1.26 ± 0.44 μg/mL) in a 5-day MTT assay. Novel and more potent derivatives of betulinic acid (2, 4, 6–8) have been synthesized with IC50 less than 0.4 μg/mL. The endothelial cell specificity against human tumor cell lines DU145, L132, A549, and PA-1 were determined. Further betulinic acid (1) inhibited TLS formation of ECV304 cells on MatrigelTM by 5.5% while its derivatives caused an inhibition of 13.1–49.2%.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794363
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