Author/Authors :
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Todd Black، نويسنده , , Aileen Soriano، نويسنده , , Wenjun Zhao، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده ,
Abstract :
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC50 of 4 and 5 μM, respectively.
