Title of article
Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum
Author/Authors
Vinod R. Hegde، نويسنده , , Haiyan Pu، نويسنده , , Mahesh Patel، نويسنده , , Todd Black، نويسنده , , Aileen Soriano، نويسنده , , Wenjun Zhao، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
2275
To page
2277
Abstract
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC50 of 4 and 5 μM, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794383
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