Title of article
Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors
Author/Authors
Hyun-Suk Lim، نويسنده , , Jeong-Ju Park، نويسنده , , Kwangseok Ko، نويسنده , , Mee-Hyun Lee، نويسنده , , Sung-Kee Chung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2499
To page
2503
Abstract
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Keywords
Sphingosine-1-phosphate analogues , EDG/S1P receptors , Relative binding affinities , Structure–activity relationships.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794426
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