Author/Authors :
David G. Barrett، نويسنده , , John G. Catalano، نويسنده , , David N. Deaton، نويسنده , , Stacey T. Long، نويسنده , , Larry R. Miller، نويسنده , , Francis X. Tavares، نويسنده , , Kevin J. Wells-Knecht، نويسنده , , Lois L. Wright، نويسنده , , Hui-Qiang Q. Zhou، نويسنده ,
Abstract :
An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P1′ elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors.
Keywords :
Cathepsin K , Cysteine protease inhibitors.* Corresponding author. Tel.: +1-919-483-6270 , fax: +1-919-315-0430 , Ketoamide
