Author/Authors :
Yurngdong Jahng، نويسنده , , Long-Xuan Zhao، نويسنده , , Yoon-Soo Moon، نويسنده , , Arjun Basnet، نويسنده , , Eunkyung Kim، نويسنده , , Hyeun Wook Chang، نويسنده , , Hye Kyung Ju، نويسنده , , Tae Cheon Jeong، نويسنده , , Eung Seok Lee، نويسنده ,
Abstract :
For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C15 showed the most significant dual COX/5-LOX inhibitory activity.
