Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters

A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a–j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g–j) displayed significant inhibitory activity of the enzyme.