Title of article :
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea––synthesis and structure–activity relationships
Author/Authors :
Hing L. Sham، نويسنده , , David A. Betebenner، نويسنده , , William Rosenbrook، نويسنده , , Thomas Herrin، نويسنده , , Ayda Saldivar، نويسنده , , Sudthida Vasavanonda، نويسنده , , Jacob J. Plattner، نويسنده , , Daniel W. Norbeck، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
3
From page :
2643
To page :
2645
Abstract :
The HIV protease inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure–activity relationships explored.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2004
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
794455
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794455
بازگشت