Author/Authors :
Tatsuhiro Yamamoto، نويسنده , , Kenjiro Ikuta، نويسنده , , Keiji Oi، نويسنده , , Kohtaro Abe، نويسنده , , Toyokazu Uwatoku، نويسنده , , Fuminori Hyodo، نويسنده , , Masaharu Murata، نويسنده , , Noboru Shigetani، نويسنده , , Kengo Yoshimitsu، نويسنده , , Hiroaki Shimokawa، نويسنده , , Hideo Utsumi، نويسنده , , Yoshiki Katayama، نويسنده ,
Abstract :
A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.
Keywords :
Vascularendothelial injury. , MRI contrast agent , cardiovascular disease , MRI
