Title of article
Antimelanomal activity of the copper(II) complexes of 1-substituted 5-amino-imidazole ligands against B16F10 mouse melanoma cells
Author/Authors
Uday Sandbhor، نويسنده , , Pallavi Kulkarni، نويسنده , , Subhash Padhye، نويسنده , , Gopal Kundu، نويسنده , , Grahame Mackenzie، نويسنده , , Robin Pritchard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
2877
To page
2882
Abstract
The copper complexes of 5-amino-imidazole ligands were prepared and characterized by various spectroscopic techniques. The ligand geometry around the copper(II) centre is square pyramidal based on N2O2 donor atoms and a coordinated water molecule at the apex. Single crystal X-ray structures were determined for both ligands. Ligands and copper complexes exhibited dose-dependent antiproliferative effects on the growth of B16F10 melanoma cells line but lower IC50 values were observed for the copper complexes.
Keywords
Amino-imidazole , Antimelanomal compounds , X-ray structure. , Copper complexes
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794501
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