Title of article :
Porphyrin–DNA cross-linking agent hybrids: chemical synthesis and biological studies
Author/Authors :
Hanping He، نويسنده , , Tian-Tian Li، نويسنده , , Ping Wang، نويسنده , , Lin Wu، نويسنده , , Jingjing Xu، نويسنده , , Xiang Zhou، نويسنده , , Xiaolian Zhang، نويسنده , , Xiaoping Cao، نويسنده , , Xiaojun Wu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Three new porphyrin–DNA cross-linking conjugates 8, 9, and 10 have been synthesized. Their photoinduced DNA cleavage activity have been studied. The IC50 values to THP-1 cells in the presence of porphyrin derivatives 8, 9, and 10 with photoirradiation were 5.6, 88.4, and 61.8 nM, respectively.
Keywords :
Photocleavage , DNA cross-linking , Anti-tumor agent.* Corresponding authors. Tel.: +86-27-87645382 , fax: +86-27-87336-380 , e-mail: zhouxiang65@hotmail.com
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
