Title of article
Discovering selective agonists of endothelial target for acetylcholine (ETA) via diversity-guided pharmacophore simplification and simulation
Author/Authors
Rifang Yang، نويسنده , , Rusheng Zhao، نويسنده , , Dongmei Chen، نويسنده , , Limei Shan، نويسنده , , Liuhong Yun، نويسنده , , Hai Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
9
From page
3017
To page
3025
Abstract
Two types of lead structures for selective agonists of ETA, a biological target not yet fully elucidated, has first been discovered via diversity-guided pharmacophore simplification and simulation. And it is first demonstrated that potent selective ETA agonists might be useful for protection of endothelium and for prophylaxis and treatment of cardiovascular diseases with endothelial dysfunction such as atherosclerosis and thrombosis.
Keywords
Agonist , Pharmacophore simulation. , Diversity , Endothelial target for acetylcholine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794528
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