Author/Authors :
Michele A. Weidner-Wells، نويسنده , , Harvey M. Werblood، نويسنده , , Raul Goldschmidt، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Barbara D. Foleno، نويسنده , , Jamese J. Hilliard، نويسنده , , John Melton، نويسنده , , Ellyn Wira، نويسنده , , Mark J. Macielag، نويسنده ,
Abstract :
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
Keywords :
Antibacterial , oxazolidinone , fax: +1-908-203-8109 , e-mail: mwells@prdus.jnj.com , Resistant bacteria.* Corresponding author. Tel.: +1-908-704-5933
