Title of article :
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist
Author/Authors :
Daniel P. Becker، نويسنده , , Daniel L. Flynn، نويسنده , , Clara I. Villamil، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.
Keywords :
Serotonin , SC-53116 , Pyrrolizidine.* Corresponding author at present address: Department of Chemistry , Loyola University , 6525 North Sheridan Road , Chicago , IL 60626 , USA. Tel.: +1-8477297455 , fax: +1-8477303181 , e-mail: dbecke3@luc.edu , Prokinetic , 5-HT4
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
