Title of article
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
Author/Authors
Paul F. van Swieten، نويسنده , , Rene Maehr، نويسنده , , Adrianus M.C.H. van den Nieuwendijk، نويسنده , , Benedikt M. Kessler، نويسنده , , Michael Reich، نويسنده , , Chung-Sing Wong، نويسنده , , Hubert Kalbacher، نويسنده , , Michiel A. Leeuwenburgh، نويسنده , , Christoph Driessen، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Hidde L. Ploegh، نويسنده , , Herman S. Overkleeft، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3131
To page
3134
Abstract
Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.
Keywords
cysteine proteases , Active site-directed probe , Isotopiclabeling , suicide inhibitor , synthesis , Chemical proteomics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794549
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