Author/Authors :
Min Amy Xiang، نويسنده , , Robert H. Chen، نويسنده , , Keith T. Demarest، نويسنده , , Joseph Gunnet، نويسنده , , Richard Look، نويسنده , , William Hageman، نويسنده , , William V. Murray، نويسنده , , Donald W. Combs، نويسنده , , Philip J. Rybczynski، نويسنده , , Mona Patel، نويسنده ,
Abstract :
A series of substituted spirobenzazepines was prepared and evaluated as V1a and V2 dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.
