Title of article :
Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth
Author/Authors :
Martin Sendzik، نويسنده , , James W. Janc، نويسنده , , Ronnel Cabuslay، نويسنده , , Lee Honigberg، نويسنده , , Richard L. Mackman، نويسنده , , Catherine Magill، نويسنده , , Neil Squires، نويسنده , , Nancy Waldeck، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The rational design and synthesis of β-amino-α-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described.
Keywords :
MetAP2 , Reversible inhibitor , HUVEC.* Corresponding author. Tel.: +1-650-866-6533 , Angiogenesis , fax: +1-650-866-6655 , e-mail: martin.sendzik@celera.com
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
