Title of article
Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis
Author/Authors
Christian Beaulieu، نويسنده , , Zhaoyin Wang، نويسنده , , Danielle Denis، نويسنده , , Gillian Greig، نويسنده , , Sonia Lamontagne، نويسنده , , Gary OʹNeill، نويسنده , , Deborah Slipetz، نويسنده , , Jennifer Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3195
To page
3199
Abstract
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure–activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.
Keywords
DP antagonist.* Corresponding author. Tel.: +1-514-4283297 , fax: +1-514-4284900 , e-mail: christian_beaulieu@merck.com , Benzimidazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794564
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