Title of article :
Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors
Author/Authors :
Rumiko Shimazawa، نويسنده , , Toshiyuki Suzuki، نويسنده , , Kosuke Dodo، نويسنده , , Ryuichi Shirai، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D3. These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC50=0.44–0.89 μM).
Keywords :
Dual-specificity phosphatase , Enzymeinhibitor , Cdc25A , Vitamin D3. , Dysidiolide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
