Title of article :
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers
Author/Authors :
Yong Sup Lee، نويسنده , , Bum Hoon Lee، نويسنده , , Seong Jun Park، نويسنده , , Soon Bang Kang، نويسنده , , Hyewhon Rhim، نويسنده , , Jin-Yong Park، نويسنده , , Jung-Ha Lee، نويسنده , , Seong-Woo Jeong، نويسنده , , Jae Yeol Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
For LVA T-type Ca2+ channel blockers, 3,4-dihydroquinazoline derivatives as new scaffolds were prepared and evaluated for the inhibitory activity against two members of the recombinant T-type Ca2+ channel family. Among them, 8a (KYS05001, IC50=0.9 μM) was nearly equipotent with mibefradil (IC50=0.84 μM) and inhibited LVA T-type Ca2+ channel with greater efficacy than HVA Ca2+ channel.
Keywords :
3 , 4-Dihydroquinazolines , T-type calcium channel , Mibefradil.* Corresponding author. Tel.: +82-2-9610726 , e-mail: ljy@khu.ac.kr , blockers , fax: +82-2-9663701
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
