Synthesis of S-alkyl -homocysteine analogues of glutathione and their kinetic studies with γ-glutamyl transpeptidase

A series of S-alkyl -homocysteine analogues of glutathione was synthesized with varied oxidation state of the sulfur and tested for inhibition of rat kidney γ-glutamyl transpeptidase (GGT). The strong selectivity of the enzyme with respect to the sulfur oxidation state reveals important information for the development of powerful competitive inhibitors.