Title of article
Synthesis and biological activity of some known and putative duloxetine metabolites
Author/Authors
F. Kuo، نويسنده , , T. A. Gillespie، نويسنده , , P. Kulanthaivel، نويسنده , , R. J. Lantz، نويسنده , , T. W. Ma، نويسنده , , D. L. Nelson، نويسنده , , P. G. Threlkeld، نويسنده , , W. J. Wheeler، نويسنده , , P. Yi، نويسنده , , M. Zmijewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
3481
To page
3486
Abstract
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794619
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