Author/Authors :
Kenneth L. Smith، نويسنده , , Vicky C. H. Lai، نويسنده , , Brett J. Prigaro، نويسنده , , Yili Ding، نويسنده , , Esmir Gunic، نويسنده , , Jean-Luc Girardet، نويسنده , , Weidong Zhong، نويسنده , , Zhi Hong، نويسنده , , Stanley Lang، نويسنده , , Haoyun An، نويسنده ,
Abstract :
Ten new β- -ribofuranosyl and 2′-β-C-methyl-β- -ribofuranosyl triciribine derivatives 4–13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2′-β-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.
