Author/Authors :
Sung-Yu Hong، نويسنده , , Kwang-Hoe Chung، نويسنده , , Hea-Jung Kim، نويسنده , , Ik Hwa Choi، نويسنده , , Mi Jin Chae، نويسنده , , Ja-Young Han، نويسنده , , Ok-Jai Jung، نويسنده , , Soo-Jung Kang، نويسنده , , Chung-Kyu Ryu، نويسنده ,
Abstract :
A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
